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With analytical chromatography, separations are measured by retention time, or the speed of separation. With flash chromatography, the more usual measurement is column volume, or the volume of solvent used. These differences are shown in the table below:
| Analytical Chromatography | Flash Chromatography | |
|---|---|---|
| Sample Retention: | No | Yes |
| Injection Method: | Important | Not important |
| Dead Volume: | Need to eliminate | Less crucial |
| Accurate Timing: | Highly important | Less important |
| Separation Power: | High (40k theoretical plates) | Low (2k theoretical plates |
Thus, the precision of the equipment used is not as important and the cost declines as a result.
Due to the relationship between column volume and the separation, accurate determinations of a separation can still be made.
